WebJun 1, 2024 · To further investigate the relationship of the expression profiles of Fkbp5, Nr3c1, and Nr3c2, we took advantage of a publicly available single-cell RNA sequencing dataset consisting of 113,507 single cells isolated from the mouse hippocampus (Saunders et al., 2024).The single-cell expression data revealed a complex cellular composition, … WebMar 21, 2024 · FKBP5 (FKBP Prolyl Isomerase 5) is a Protein Coding gene. Diseases associated with FKBP5 include Major Depressive Disorder and Asthma . Among its related pathways are Gene expression …
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WebThe FKBP s, or FK506 binding proteins, constitute a family of proteins that have prolyl isomerase activity and are related to the cyclophilins in function, though not in amino acid sequence. [1] FKBPs have been identified in many eukaryotes, ranging from yeast to humans, and function as protein folding chaperones for proteins containing proline ... WebAlong these lines, analyses of the ratio of the number of cells expressing Fkbp5 and Nr3c2, but not Nr3c1, to the number of cells expressing Fkbp5 and Nr3c1, but not Nr3c2, further confirmed this cluster-dependent relationship of Fkbp5 and the two receptors (Yates’ chi-square = 854.177; p < 2.2e−16), with cluster CA2/CA3 representing a ... greenlaw drive virginia beach
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WebApr 3, 2024 · FKBP5 is involved in the regulation of neuroendocrine stress mechanisms,multiple polymorphisms in FKBP5 have proven to be correlated with stress … WebFKBP5. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … WebC57BL/6NTac-Fkbp5tm4570(FKBP5)Tac carrying the risk-associated rs1360780-A/T. The targeting strategy allows the generation of a constitutive humanization of the Fkbp5 gene. The targeting strategy is based on NCBI transcripts NM_010220_4 (mouse) and NM_001145775_2 (human). Exon 2 contains the translation initiation codon. greenlaw duncan