Cisplatin function

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August undefined, 2024

WebNov 10, 2024 · Many widely-used chemotherapies, like cisplatin, kill tumors by damaging their DNA and inducing programmed cell death. But cells are resilient, and many can continue to function with the help of repair enzymes that simply bypass the damage and continue to replicate the DNA. WebFeb 16, 2016 · Cisplatin is standardly dosed in a three-weekly schedule of 100 mg/m 2 (total dose 300 mg/m 2) combined with standard RT [ 3, 6, 7, 9, 10 ]. However, a high-dose cisplatin regimen is associated with major toxic side effects (myelosuppression, neurotoxicity, ototoxicity, and nephrotoxicity).

News Brief: Enhancing chemotherapy - MIT Department of Biology

WebCisplatin is a type of chemotherapy. It destroys quickly dividing cells, such as cancer cells. Find out more about how chemotherapy works How do you have cisplatin? You have cisplatin as a drip into your bloodstream (intravenously). Into your bloodstream You might have treatment through a long plastic tube that goes into a large vein in your chest. WebCisplatin(cis-dichlorodiammineplatinum)–platinum coordination complex is an effective chemotherapy against a wide spectrum of tumors such as testicular, head and neck, … simply novel

Chapter 11. Chemotherapy and Kidney Injury - American …

WebCisplatin is a chemotherapy medication used to treat a number of cancers. [2] These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, … WebApr 14, 2024 · Thus, the aim of this work was to carry out a non-targeted metabolomic approach to study if the apoptotic stimulus (cisplatin or UV light) affects in a different way the metabolites involved in the propagation of apoptosis. Both ABs and their extracellular fluid were analyzed using a reverse-phase liquid chromatography-mass spectrometry setup. WebApr 14, 2024 · Histone acetylation plays a vital role in organizing chromatin, regulating gene expression and controlling the cell cycle. The first histone acetyltransferase to be identified was histone acetyltransferase 1 (HAT1), but it remains one of the least understood acetyltransferases. HAT1 catalyzes the acetylation of newly synthesized H4 and, to a … raytown first baptist church

Cisplatin - an overview ScienceDirect Topics

Cisplatin Dosage Guide + Max Dose, Adjustments - Drugs.com

WebVarious recent studies have investigated (GLP-1R) role in cardiovascular diseases due to antiapoptotic and antioxidant effects. The current study aimed to investigate the curative … WebApr 6, 2024 · Cisplatin is a cytostatic agent and it is used to treat various cancer types, including cancer of ovary, testis, lung, head, neck, bladder, neuroblastoma, and nephroblastoma, and Hodgkin’s disease and non-Hodgkin lymphoma. Uses muscle relaxant (skeletal) Uses Used as an antineoplastic Uses antitumor agent Definition simply nourish wet cat foodWebFeb 16, 2024 · Aluminum reacts with this drug, causing precipitate formation and a loss of potency. Monitoring: Peripheral blood counts should be monitored weekly. Liver function should be monitored periodically. Neurologic examination should be performed regularly. More about cisplatin Further information simply nozipho

"WebOct 5, 2014 · Exposure to oxidative stress can upset regular biological functions. Cisplatin also induces reactive oxygen species that trigger cell death besides DNA damage. … " - Cisplatin function

Cisplatin function

Cisplatin (chemotherapy drug) - treatment and side effects

WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is … WebJul 18, 2024 · For induction of remissions, a regimen of cisplatin, bleomycin, and vinblastine (with or without other antineoplastic agents) has been used. For treatment of disseminated disease, a regimen of cisplatin, bleomycin, and etoposide has been used.

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WebThe cisplatin molecule binds with a protein on one side and the DNA molecule on the other. The protein is critical; it protects the cisplatin molecule from being removed by DNA repair mechanisms in the cell. New combination regimens are often tried in clinical trials, and it is common for newly … WebCisplatin, a chemotherapy medication used to treat BC, not only rapidly kills proliferating cancer cells but also affects the tumor immune microenvironment. However, the mechanism underlying this phenomenon is largely unknown.

WebPurpose: The objective of this study was to develop a pH-dependent calcium carbonate nano-delivery system for the combination therapy of CDDP with oleanolic acid (OA). Methods: A microemulsion method was employed to generate lipid coated cisplatin/oleanolic acid calcium carbonate nanoparticles (CDDP/OA-LCC NPs), and the … WebJan 17, 2014 · Cisplatin is a widely used and highly effective cytotoxic agent, including for nasopharyngeal carcinoma (NPC). One of the side effects of cisplatin is nephrotoxicity, especially in tubulus....

WebAug 6, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A known complication of … WebCisplatin has disturbed mitochondrial function and dynamics, dysregulate redox status and induced mitophagy and apoptosis, in the other hand semaglutide treatment has normalized dysregulated mitochondrial function and dynamics, …

WebCisplatin stimulates production of reactive oxygen species and oxidative stress by depleting and inactivating glutathione and other related antioxidants. • Cisplatin induces both …

WebSep 1, 2024 · Cisplatin for injection is indicated for the treatment of advanced testicular cancer. Advanced Ovarian Cancer Cisplatin for injection is indicated for the treatment of … raytown fitness centerWebCisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney toxicities. This review details those biochemical pathways and metabolic conversions that underlie the kidney toxicities. simply nowWebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. raytown flowersWebThe repair function of MMR proteins has been reported to be uncoupled from their function in mediating cisplatin-induced cell death [56–58]. Since the primary mechanism of cisplatin involves DNA damage and p53 is also involved in DNA damage signaling, there are many studies that correlate cisplatin and DNA damage and repair with p53 activity ... raytown flexWebTMEPAI was known to be induced by TGF-β/Smad signaling and have tumorigenic functions that converting TGF-β from tumor suppressor to tumor promoter and inducing epithelial–mesenchymal transition (EMT). ... (IC50) of several anti-cancers: doxorubicin, cisplatin, paclitaxel, and bicalutamide in the presence of TGF-β treatment.Results: KO ... raytown food deliveryWebWhat Cisplatin Is Used For: Treatment of advanced bladder cancer, metastatic ovarian cancer, and metastatic testicular cancer. Testicular, ovarian, bladder, head and neck, … raytown footballWebcisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric Dosage … simply nr