Cisplatin and electrolytes

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August undefined, 2024

WebApr 15, 2024 · Additionally, cisplatin-induced nephrotoxicity led to the unmasking of a familial form of hypomagnesemia. ... Previously, the baseline electrolyte profile was normal. He was suspected to have nephrotoxicity complicated by acute hypomagnesaemia. Hence, the boy was treated with supplementation and hypomagnesaemia recovered … WebAt one hour after cisplatin injection, the intestinal segment was perfused in situ with plasma electrolyte solution (Na 140 mmol/l, K 4 mmol/l, HCO 3 40 mmol/l, Cl 104 mmol/l) …

Basic Concepts of Fluid and Electrolyte Balance - ResearchGate

WebFeb 16, 2016 · Purpose: Loco-regional control and organ preservation are significantly improved with concomitant cisplatin/radiotherapy and are compromised with less than 5% grade 3 nephrotoxicity (creatinine clearance 15–29 mL/min). However, although clinically important, in none of the randomized trials is grade 2 nephrotoxicity (defined as … WebIts signs include lethargy, vomiting, and general muscle weakness (Anand & Nikhil, 2024). As an electrolyte, calcium helps in keeping bones healthy and a lack of this leads to general tiredness especially on the aged patients. FLUID AND ELECTROLYTE 6 References Anand, A. S., & Nikhil, S. (2024). scary mugshots

Cisplatin: Package Insert - Drugs.com

WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and neck, bladder, ovarian, and testicular malignanc Cisplatin-Induced Acute Kidney Injury and Renal Salt Wasting Syndrome Federal Practitioner WebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class of cytotoxic medications. This activity reviews the indications, action, and contraindications for cisplatinum as a valuable agent in treating malignancy. scary msm

Cisplatin impairs fluid and electrolyte absorption in rat small ... - Gut

Cisplatin - an overview ScienceDirect Topics

WebNephrotoxicity: cisplatin for injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate … WebSep 23, 2024 · Background Cisplatin is an important drug in the treatment of various Cancers. However, this drug causes nephrotoxicity that is linked to electrolyte derangement. The aim of this study was to evaluate the effect of electrolyte supplementation in reducing kidney injury in patients receiving cisplatin-based regimen. scary ms teams backgroundWebMay 19, 2024 · Electrolyte disorders are also related to cisplatin-induced DNA damage of thiazide-sensitive sodium-chloride co-transporter genes and to the apoptosis of distal tubule cells ( 34 ). Cisplatin treatment may … scary mtv show

"WebJan 1, 2015 · Background: Cisplatin, one of the most commonly used chemotherapeutic agents, has electrolyte imbalances as one of its most important adverse effects. We conducted this study to characterize... " - Cisplatin and electrolytes

Cisplatin and electrolytes

Cisplatin (UK PID) - International Programme on Chemical Safety

WebCisplatin for injection is a highly emetogenic antineoplastic agent; premedicate with anti-emetic agents; without antiemetic therapy, marked nausea and vomiting occur in almost … WebDec 2, 2014 · Cisplatin is one of the most widely used and highly effective drug for the treatment of various solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and nerves. Nephrotoxicity is the …

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WebCisplatin and ifosfamide can cause kidney damage. This can be lessened by giving lots of fluids (usually into a vein – IV) before and after these drugs are given. Cisplatin, etoposide, paclitaxel, and vinblastine can damage nerves (known as neuropathy ). This can lead to numbness or tingling in the hands and feet, and sensitivity to cold or heat. WebJun 8, 2024 · Cisplatin injection, is a clear, colorless to pale yellow, sterile aqueous solution available in sterilie multiple-dose vials containing - 50 mg/50 mL (1 mg/mL) 100 mg/100 mL (1 mg/mL) 4 CONTRAINDICATIONS Cisplatin injection is contraindicated in patients with severe hypersensitivity to cisplatin - [see Warnings and Precautions ( 5.4) ...

WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … WebMar 1, 2024 · Lasix is a strong diuretic that increases urination and relieves excess fluid from the body. This may also lead to the depletion of certain electrolytes, such as potassium. 5. Tips Dosages vary from individual to individual and people taking high dosages may need extra monitoring by their doctor.

WebSep 21, 2024 · Common side effects of furosemide include low blood pressure, dehydration, electrolyte depletion, yellowing of skin and eyes (jaundice), ringing in the ears (tinnitus), sensitivity to light, rash, pancreatitis, nausea, diarrhea, abdominal pain, dizziness, increased blood sugar, and increased uric acid levels. WebCisplatin solution for injection: Clear, practically colourless solution in amber glass vials containing cisplatin 1mg/ml, sodium chloride 9mg/ml and mannitol 1mg/ml with a pH of 3.5-4.0. 2 SUMMARY The principal target organ for cisplatin toxicity is the kidney.

WebMar 1, 2024 · A case of an elderly male presenting with significant recurrent hyponatremia, and prerenal azotemia, with recent exposure to cisplatin along with significant hypovolemia and urinary loss of sodium is reported. Cisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude …

WebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects. scary multiplayer games crossplayWebSep 26, 2024 · While generally mild electrolyte deficiencies are pretty benign, moderate/severe abnormalities can cause many life-threatening conditions, including cardiac arrhythmias, seizures, muscle paralysis, … scary mule ride grand canyonWebPrevention and management of cisplatin nephrotoxicity. ID: 184 v.3. Endorsed. This document is an evidence based summary to complement treatment protocols and includes background and rationale for specific point of care actions. It is not intended to be a comprehensive literature review of all available evidence. scary multiplayer games free pcWebMay 18, 2024 · Fluid, electrolyte and acid-base disorders associated with antibiotic therapy. Nat Rev Nephrol 2009; 5:193. Canada TW, Weavind LM, Augustin KM. Possible liposomal amphotericin B-induced nephrogenic diabetes insipidus. Ann Pharmacother 2003; 37:70. Sacks P, Fellner SK. Recurrent reversible acute renal failure from amphotericin. scary multiplayer gameWebApr 12, 2024 · As previously described, also the cisplatin can induce electrolyte imbalances. In this case, the standard approach to avoid cisplatin-induced nephrotoxicity and the consequent electrolyte alteration is the administration of IV isotonic saline solution in order to stimulate the diuresis. Some authors suggest to add 2 gr of magnesium … run as administrator using cmdWebCisplatin revealed higher cytotoxicity towards established cell lines. Following CisEP application, we observed a significant decrease of cells viability in the primary culture … scary muchWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … scary multiplayer games